MRI, hybrid imaging outperform conventional tests for small cell lung cancer staging

Journal Reference:

  1. Yoshiharu Ohno, Takeshi Yoshikawa, Daisuke Takenaka, Hisanobu Koyama, Kota Aoyagi, Masao Yui, Yuka Oshima, Nayu Hamabuchi, Yumi Tanaka, Chika Shigemura, Seiichiro Oota, Masahiko Nomura, Kazuhiro Murayama, Yoshitaka Inui, Kaoru Kikukawa, Hiroshi Toyama. Small Cell Lung Cancer Staging: Prospective Comparison of Conventional Staging Tests, FDG PET/CT, Whole-Body MRI, and Coregistered FDG PET/MRI. American Journal of Roentgenology, 2021; DOI: 10.2214/AJR.21.26868

“FDG PET/CT, whole-body MRI, and coregistered FDG PET/MRI outperformed conventional tests for various staging endpoints in patients with SCLC,” concluded first author Yoshiharu Ohno from the Fujita Health University School of Medicine in Japan. Whole-body MRI and FDG PET/MRI outperformed FDG PET/CT for T category and thus TNM stage, “indicating utility of MRI for assessing extent of local invasion in SCLC.”

Ohno and colleagues’ prospective study included 98 patients (64 men, 34 women; median age, 74 years) with SCLC who underwent conventional staging tests (brain MRI; neck, chest, and abdominopelvic CT; bone scintigraphy), FDG PET/CT, and FDG PET/MRI within 2 weeks before treatment. After MRI technologists performed coregistration via proprietary software (Canon Medical Systems), two nuclear medicine physicians and two chest radiologists independently reviewed the examinations in separate sessions.

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“These additional observations may relate to a superior role of MRI in assessing the extent of local soft tissue invasion by tumor, as has been observed in settings other than SCLC,” added the authors of this AJR article.

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MRI, hybrid imaging outperform conventional tests for small cell lung cancer staging

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